منابع مشابه
Inferring genomic flux in bacteria.
Acquisition and loss of genetic material are essential forces in bacterial microevolution. They have been repeatedly linked with adaptation of lineages to new lifestyles, and in particular, pathogenicity. Comparative genomics has the potential to elucidate this genetic flux, but there are many methodological challenges involved in inferring evolutionary events from collections of genome sequenc...
متن کاملInferring Regulatory Signal from Genomic Data
2008 i ACKNOWLEDGEMENTS I am greatly indebted to Dr. Sung Wing-Kin for being my supervisor in this project. He has been unyielding in providing me with guidance and inspiration. Our many invaluable discussions helped me significantly to navigate through the research process. I extend my utmost gratitude for his constant encouragement and support. Karuturi Radha Krishna Murthy for the many great...
متن کاملInferring tumor progression from genomic heterogeneity.
Cancer progression in humans is difficult to infer because we do not routinely sample patients at multiple stages of their disease. However, heterogeneous breast tumors provide a unique opportunity to study human tumor progression because they still contain evidence of early and intermediate subpopulations in the form of the phylogenetic relationships. We have developed a method we call Sector-...
متن کاملInferring Correlation Networks from Genomic Survey Data
High-throughput sequencing based techniques, such as 16S rRNA gene profiling, have the potential to elucidate the complex inner workings of natural microbial communities - be they from the world's oceans or the human gut. A key step in exploring such data is the identification of dependencies between members of these communities, which is commonly achieved by correlation analysis. However, it h...
متن کاملEvolutionary Origins of Genomic Repertoires in Bacteria
Explaining the diversity of gene repertoires has been a major problem in modern evolutionary biology. In eukaryotes, this diversity is believed to result mainly from gene duplication and loss, but in prokaryotes, lateral gene transfer (LGT) can also contribute substantially to genome contents. To determine the histories of gene inventories, we conducted an exhaustive analysis of gene phylogenie...
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ژورنال
عنوان ژورنال: Genome Research
سال: 2008
ISSN: 1088-9051
DOI: 10.1101/gr.082263.108